Reactome | Pellino1, 2 and possibly 3 are believed to directly catalyse...

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created	[InstanceEdit:8948068] Jupe, Steve, 2016-11-10
dbId	8948059
displayName	Pellino1, 2 and possibly 3 are believed to directly catalyse...
literatureReference	[LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling [LiteratureReference:451426] Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase [LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation [LiteratureReference:451417] Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation [LiteratureReference:451409] Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases
schemaClass	Summation
text	Pellino1, 2 and possibly 3 are believed to directly catalyse polyubiquitylation of IRAK1 (Xiao et al. 2008; Butler et al. 2007; Ordureau et al. 2008). Following ubiquitination IRAK1 dissociates.

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