The transcriptional repressor SNAI1 (Snail1) binds the promo...

created [InstanceEdit:8944027] Orlic-Milacic, Marija, 2016-11-01
dbId 8944025
displayName The transcriptional repressor SNAI1 (Snail1) binds the promo...
modified [InstanceEdit:8944076] Orlic-Milacic, Marija, 2016-11-02
schemaClass Summation
text The transcriptional repressor SNAI1 (Snail1) binds the promoter of the PTEN gene. Binding of SNAI1 to the PTEN promoter increases in response to ionizing radiation and interferes with binding of TP53 to the PTEN promoter. Phosphorylation of SNAI1 at serine residue S246 may be required for SNAI1-mediated repression of PTEN transcription (Escriva et al. 2008). Another Slug/Snail family member SNAI2 (SLUG) can also bind to the PTEN gene promoter to repress PTEN transcription (Uygur et al. 2015).
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