Reactome | Friedman, AD

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Friedman, AD Show undefined attributes

created	[InstanceEdit:8939558] Orlic-Milacic, Marija, 2016-09-20
dbId	8939553
displayName	Friedman, AD
firstname	Alan D
initial	AD
publications	[LiteratureReference:9622389] C/EBP? in normal and malignant myelopoiesis [LiteratureReference:9616882] Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha [LiteratureReference:8939557] Cell cycle and developmental control of hematopoiesis by Runx1 [LiteratureReference:9639352] SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis [LiteratureReference:9616841] CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor [LiteratureReference:9674915] M-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification [LiteratureReference:9616272] The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells [LiteratureReference:9616220] The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBP?, PU.1, and Additional Ets Factors [LiteratureReference:9616265] Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis [LiteratureReference:9616838] Granulopoiesis requires increased C/EBP? compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells [LiteratureReference:9616884] Induction of granulocytic differentiation by 2 pathways
schemaClass	Person
surname	Friedman

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