The RUNX1:CBFB complex directly regulates transcription of a...

created [InstanceEdit:8939516] Orlic-Milacic, Marija, 2016-09-19
dbId 8939517
displayName The RUNX1:CBFB complex directly regulates transcription of a...
modified [InstanceEdit:8957316] Orlic-Milacic, Marija, 2017-01-24
schemaClass Summation
text The RUNX1:CBFB complex directly regulates transcription of at least two components of WNT signaling. In association with its co-factor FOXP3, the RUNX1:CBFB complex stimulates transcription of the RSPO3 gene, encoding a WNT ligand that is implicated as a breast cancer oncogene (Recouvreux et al. 2016). In association with the activated estrogen receptor alpha (ESR1), the RUNX1:CBFB complex stimulates the expression of AXIN1, which functions as a regulator of WNT signaling (Stender et al. 2010).
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