Vanin (VNN1) is a membrane pantetheine hydrolase or pantethe...

created [InstanceEdit:8938999] Jupe, Steve, 2016-09-15
dbId 8939006
displayName Vanin (VNN1) is a membrane pantetheine hydrolase or pantethe...
literatureReference
modified [InstanceEdit:9837407] D'Eustachio, Peter, 2023-06-14
schemaClass Summation
text Vanin (VNN1) is a membrane pantetheine hydrolase or pantetheinase (EC 3.56.1.-) (Maras et al. 1999, Martin et al. 2001), part of a cluster of three human orthologous genes (VNN1, VNN2, VNN3) on Chr. 6q22-24 (Kaskow et al. 2012, Boersma et al. 2014). VNN3 is a pseudogene in humans. Vanins catalyse the hydrolysis of pantetheine to pantothenic acid (PanK, vitamin B5) and cysteamine (2AET), a powerful anti-oxidant. PanK is the initial substrate for the synthesis of Coenzyme A (CoA-SH).

Mouse Vnn1 has been shown to be GPI-anchored to the outer face of the plasma membrane. Sequence motifs conserved with human VNN1 and VNN2 supports the inference that the human proteins are similarly anchored (Aurand-Lions et al. 1996; Naquet et al. 2020), so the enzymes are annotated as acting on extracellular panthetheine to generate extracellular PanK and 2AET.
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