CDK6 binds to the Runt domain of RUNX1 and interferes with R...

created [InstanceEdit:8938851] Orlic-Milacic, Marija, 2016-09-12
dbId 8938852
displayName CDK6 binds to the Runt domain of RUNX1 and interferes with R...
modified [InstanceEdit:8957311] Orlic-Milacic, Marija, 2017-01-24
schemaClass Summation
text CDK6 binds to the Runt domain of RUNX1 and interferes with RUNX1 binding to DNA and transcription co-factors. Formation of the RUNX1:CBFB complex does not affect the ability of CDK6 to interact with RUNX1. Neither the catalytic activity nor the cyclin-binding activity of CDK6 are required for its association with RUNX1 (Fujimoto et al. 2007).
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