The RUNX1:CBFB complex associates with the polycomb represso...

created [InstanceEdit:8937982] Orlic-Milacic, Marija, 2016-09-07
dbId 8937994
displayName The RUNX1:CBFB complex associates with the polycomb represso...
modified [InstanceEdit:8957312] Orlic-Milacic, Marija, 2017-01-24
schemaClass Summation
text The RUNX1:CBFB complex associates with the polycomb repressor complex 1 (PRC1), including components of the PRC1.4 complex (the defining subunit being BMI1) and the PRC1.5 complex (the defining subunit being PCGF5). It is possible that the RUNX1:CBFB can also associate with other PRC1 complexes. PRC1 complexes are recruited to many RUNX1:CBFB target promoters and they either positively or negatively affect the transcription of RUNX1 target genes. The definitive composition of RUNX1:CBFB:PRC1 complexes at different RUNX1 target promoters has not been determined (Yu et al. 2011).
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