Reactome | GPAM gene expression is cooperatively stimulated by RUNX1 an...

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created	[InstanceEdit:8932015] Orlic-Milacic, Marija, 2016-07-20
dbId	8932012
displayName	GPAM gene expression is cooperatively stimulated by RUNX1 an...
literatureReference	[LiteratureReference:8931984] Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation [LiteratureReference:8932023] Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
modified	[InstanceEdit:8941604] Orlic-Milacic, Marija, 2016-10-04
schemaClass	Summation
text	GPAM gene expression is cooperatively stimulated by RUNX1 and ESR1, which form a complex and bind the GPAM gene enhancer (Stender et al. 2010). GPAM encodes a glycerol-3-phosphate acyltransferase whose high expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

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