Reactome | ATF6B is anchored in the Golgi membrane and cleaved in the l...

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created	[InstanceEdit:8874818] May, Bruce, 2016-05-29
dbId	8874815
displayName	ATF6B is anchored in the Golgi membrane and cleaved in the l...
literatureReference	[LiteratureReference:9965889] CRISPR-Cas9-Mediated ATF6B Gene Editing Enhances Membrane Protein Production in HEK293T Cells [LiteratureReference:8874812] Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability
modified	[InstanceEdit:9965892] May, Bruce, 2025-09-07
schemaClass	Summation
text	ATF6B is anchored in the Golgi membrane and cleaved in the lumenal domain to release a N-terminal fragment into the cytosol (Haze et al. 2001, Guan et al. 2009, Odisho et al. 2015). By inference from SREBFs (SREBPs) and ATF6, cleavage by MBTPS2 (S2P) is believed to occur around amino acid residue 399 (Thuerauf et al. 2007). Glycosylation of 5 sites in the lumenal domain of ATF6B is required for cleavage (Guan et al. 2009). Deletion of the C-terminal domain of ATF6B causes increased production of membrane proteins, possibly due to constitutive transit of the N-terminal domain to the nucleus (Choi et al. 2025).

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