USP25, a negative regulator of the virus-triggered type I IF...

created [InstanceEdit:8869459] Jupe, Steve, 2016-05-04
dbId 8869454
displayName USP25, a negative regulator of the virus-triggered type I IF...
literatureReference
schemaClass Summation
text USP25, a negative regulator of the virus-triggered type I IFN signaling pathway, cleaves lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo from DDX58 (Retinoic acid-inducible gene I (RIG-I)), Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling (Zhong et al. 2013).
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