The short-chain dehydrogenases/reductases (SDR) family is a ...

created [InstanceEdit:8862392] Jassal, Bijay, 2016-02-26
dbId 8862386
displayName The short-chain dehydrogenases/reductases (SDR) family is a ...
modified [InstanceEdit:9943309] D'Eustachio, Peter, 2025-03-26
schemaClass Summation
text The short-chain dehydrogenases/reductases (SDR) family is a large family of NAD- or NADP-dependent oxidoreductase enzymes. 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is a recently-discovered member of this family whose physiological function is unknown (Liu et al. 2007). It has, however, been found to associate with lipid droplets and is significantly upregulated in patients with nonalcoholic fatty liver disease (NAFLD) which is characterised by an accumulation of lipid droplets in the liver. In a murine model of fatty liver and diabetes, mice with fatty livers show upregulated expression of HSD17B13, suggesting a pathogenic role for HSD17B13 in NAFLD development (Su et al. 2014). Its role in lipid droplet function under normal physiological conditions is unknown.
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