Reactome | Binding of the plasma protease C1 inhibitor (C1Inh, SERPING1...

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created	[InstanceEdit:8852474] Jupe, Steve, 2016-01-18
dbId	8852476
displayName	Binding of the plasma protease C1 inhibitor (C1Inh, SERPING1...
literatureReference	[LiteratureReference:8852466] Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1 [LiteratureReference:8852487] C1 inhibitor-dependent dissociation of human complement component C1 bound to immune complexes [LiteratureReference:8852468] Active disassembly of the first complement component, C-1, by C-1 inactivator [LiteratureReference:8852270] The first component of human complement (C1): activation and control
modified	[InstanceEdit:8867059] Jupe, Steve, 2016-04-06
schemaClass	Summation
text	Binding of the plasma protease C1 inhibitor (C1Inh, SERPING1) to the C1s and C1r subunits of the C1 complex leads to C1 disassembly, releasing inactive C1r:C1Inh and C1s:C1Inh complexes (Arlaud et al. 1979, Sim et al. 1979, Ziccardi & Cooper 1979). Thus C1Inh plays an important role in regulating nonspecific complement activation (Ziccardi et al. 1983).

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