In addition to AGER/RAGE, several other proteins have been i...
| created | [InstanceEdit:879462] Jupe, S, 2010-06-17 |
| dbId | 879431 |
| displayName | In addition to AGER/RAGE, several other proteins have been i... |
| literatureReference |
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| modified | [InstanceEdit:908577] Jupe, S, 2010-07-06 |
| schemaClass | Summation |
| text | In addition to AGER/RAGE, several other proteins have been identified as AGE-binding proteins. AGE binding proteins p60 and p90 (Yang et al. 1991) were subsequently identified as the Oligosaccharyl transferase 48 kDa subunit (Ost-48) and Glucosidease-2 subunit beta (Li et al. 1996). A third member was identified as Galectin-3 (Vlassara et al. 1995). These 3 proteins have been shown to be present on the plasma membrane of many cell types including vascular endothelium (Stitt et al. 1999). They have been designated AGE-R1, -R2 and -R3. Their suggested function is the removal and degradation of AGEs, but AGER-1 was found to negatively regulate AGER/RAGE (Lu et al. 2004), with kinetics that suggested a more complex interaction than simple competition for the same ligand. |
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