Reactome | Alessi, DR

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dbId	76776
displayName	Alessi, DR
firstname	Dario R
initial	DR
publications	[LiteratureReference:110470] 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. [LiteratureReference:162388] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha [LiteratureReference:5673954] Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1 [LiteratureReference:199331] Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B [LiteratureReference:6795317] mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) [LiteratureReference:9863608] High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate [LiteratureReference:8870326] Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1 [LiteratureReference:199367] Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB [LiteratureReference:8870319] Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis [LiteratureReference:5672801] Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs [LiteratureReference:162409] Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation [LiteratureReference:5672879] Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction [LiteratureReference:9839453] Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 [LiteratureReference:5696463] USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses [LiteratureReference:9620019] Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types [LiteratureReference:76318] Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. [LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 [LiteratureReference:5626158] TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development [LiteratureReference:6795320] Identification of Protor as a novel Rictor-binding component of mTOR complex-2 [LiteratureReference:9835093] PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 [LiteratureReference:9838790] Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation [LiteratureReference:6790404] Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer [LiteratureReference:9709690] Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
schemaClass	Person
surname	Alessi

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