Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is...

dbId 72756
displayName Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is...
literatureReference
modified [InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00
schemaClass Summation
text Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.