Reactome | Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is...

Schema > Summation > Entries

Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is... Show undefined attributes

dbId	72756
displayName	Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is...
literatureReference	[LiteratureReference:72677] Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation [LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes [LiteratureReference:72708] A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [LiteratureReference:72713] Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex [LiteratureReference:72715] The joining of ribosomal subunits in eukaryotes requires eIF5B [LiteratureReference:72721] Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors [LiteratureReference:72719] Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes
modified	[InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00
schemaClass	Summation
text	Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.

Referrals

(summation)

[Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released

© 2026 Reactome

Cite Us!