Reactome | The APAF1 interacting protein (APIP) is an endogenous regula...

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created	[InstanceEdit:6804583] Shamovsky, Veronica, 2015-10-13
dbId	6804595
displayName	The APAF1 interacting protein (APIP) is an endogenous regula...
literatureReference	[LiteratureReference:6804618] Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme [LiteratureReference:6804566] Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death [LiteratureReference:6804582] Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein [LiteratureReference:6804604] Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2
schemaClass	Summation
text	The APAF1 interacting protein (APIP) is an endogenous regulators of the apoptosome apparatus. APIP is thought to bind to the CARD domain of APAF1 preventing procaspase-9 recruitment to the apoptosome (Cho DH et al., 2004; Cao G et al., 2004; Kang W et al. 2014). Moreover, during hypoxic conditions, APIP may also induce sustained activation of AKT and ERK1/2 kinases, which directly phosphorylate procaspase-9 to inhibit its activation in the apoptosome (Cho DH et al., 2007).

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