Reactome | interleukin-34 (IL34) was identified as a potent activator o...

Schema > Summation > Entries

created	[InstanceEdit:6803177] Jupe, Steve, 2015-10-05
dbId	6803169
displayName	interleukin-34 (IL34) was identified as a potent activator o...
literatureReference	[LiteratureReference:448611] Discovery of a cytokine and its receptor by functional screening of the extracellular proteome [LiteratureReference:6803167] Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products [LiteratureReference:6803171] The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1 [LiteratureReference:8854718] Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R
modified	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
schemaClass	Summation
text	interleukin-34 (IL34) was identified as a potent activator of monocytes and macrophages, signaling through Colony-stimulating factor-1 (CSF1) receptor (CSF1R) with a distinct tissue distribution from CSF1 (Lin et al. 2008). IL34 and CSF1 share many functional properties. IL34 has no appreciable sequence similarity with any other protein but shares a four-helix bundle structure seen in CSF1 (Garceau et al. 2010, Liu et al. 2012). IL34 forms a noncovalently linked dimer (Ma et al. 2012) whereas CSF1 contains an intersubunit disulfide bond. The structure of the IL34:CSF1R complex shows a similar ligand-receptor assembly to that of CSF1:CSF1R.

(summation)

Cite Us!