Binding of TP53 (p53) to the p53 response element in the sec...

created [InstanceEdit:6801211] Orlic-Milacic, Marija, 2015-09-30
dbId 6801212
displayName Binding of TP53 (p53) to the p53 response element in the sec...
modified [InstanceEdit:8856075] Orlic-Milacic, Marija, 2016-02-08
schemaClass Summation
text Binding of TP53 (p53) to the p53 response element in the second intron of the TRIAP1 (TP53-regulated inhibitor of apoptosis, also known as p53 survival factor or p53CSV) gene induces TRIAP1 transcription (Park and Nakamura 2005). Recently, TRIAP1 has been characterized as a gene-specific repressor of p21 (CDKN1A). TRIAP1 knockdown leads to augmented p21 expression before and during p53 activation and thus slows down cell proliferation (Andrysik et al. 2013).
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