MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr...

created [InstanceEdit:6798643] May, Bruce, 2015-09-21
dbId 6798646
displayName MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr...
modified [InstanceEdit:8868774] May, Bruce, 2016-04-25
schemaClass Summation
text MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr et al. 2012, Yakubovskaya et al. 2012) and recruits NSUN4 to the ribosome where NSUN4 transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-841 in 12S rRNA (Camara et al. 2011). Knockout of MTERF4 in mice is lethal and cardiomyocyte-specific knockout is accompanied by mitochondrial cardiomyopathy (Camara et al. 2011).
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