Reactome | The protein 4.1 family includes four well-defined members: e...

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created	[InstanceEdit:6797569] Garapati, Phani Vijay, 2015-09-14
dbId	6797551
displayName	The protein 4.1 family includes four well-defined members: e...
literatureReference	[LiteratureReference:6797550] Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily [LiteratureReference:6797566] CASK and protein 4.1 support F-actin nucleation on neurexins
schemaClass	Summation
text	The protein 4.1 family includes four well-defined members: erythroid protein 4.1 (4.1R), the bestknown and characterized member, 4.1G (general), 4.1N (neuronal), and 4.1 B (brain). Protein 4.1N is a neuronal homologue of erythrocyte membrane cytoskeletal protein 4.1 (4.1R). Protein 4.1N can stabilize the plasticity of the neuronal membrane via interactions with the spectrin-actin-based skeleton, integral membrane channels and receptors, and membrane-associated guanylate kinases (Diakowski et al. 2006). This brain-specific protein 4.1N isoform intercts with CASK and recruits actin and spectrin (Biederer & Sudhof 2001).

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