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created	[InstanceEdit:6793965] Jupe, Steve, 2015-09-04
dbId	6793979
displayName	Phosphorylated Signal transducer and activator of transcript...
literatureReference	[LiteratureReference:6786053] Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma [LiteratureReference:6785812] Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells [LiteratureReference:6785804] Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription [LiteratureReference:6785885] Regulation of the germline immunoglobulin Cgamma1 promoter by CD40 ligand and IL-4: dual role for tandem NF-kappaB binding sites [LiteratureReference:3261236] Signaling mechanisms, interaction partners, and target genes of STAT6
modified	[InstanceEdit:6797418] Jupe, Steve, 2015-09-10
schemaClass	Summation
text	Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyperresponsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the extracellular proteins C-C motif chemokine 11 (CCL11, Eotaxin) (Matsukura et al. 1999), Ig epsilon chain C region (IGHE) (St�tz & Woisetschlager 1999), Ig gamma-1 chain C region (IGHG1) (Warren et al. 1999) and Ig gamma-4 chain C region (IGHG4) (Hebenstreit et al. 2006).

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[BlackBoxEvent:R-HSA-6793978] Expression of STAT6-upregulated extracellular proteins

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