Reactome | Interleukin-4 receptor alpha subunit (IL4R) and Interleukin-...

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created	[InstanceEdit:6786052] Jupe, Steve, 2015-07-03
dbId	6786073
displayName	Interleukin-4 receptor alpha subunit (IL4R) and Interleukin-...
literatureReference	[LiteratureReference:6785889] IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats [LiteratureReference:6785892] IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages [LiteratureReference:6785763] Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes
modified	[InstanceEdit:6797572] Jupe, Steve, 2015-09-14
schemaClass	Summation
text	Interleukin-4 receptor alpha subunit (IL4R) and Interleukin-13 receptor subunit alpha 1 (IL13RA1) are phosphorylated on tyrosines in response to Interleukin-13 (IL13) in human blood monocytes (Roy et al. 2002, Bhattacharjee et al. 2013). The associated Janus-kinase (JAK) family kinases JAK2 and TYK2 are also phosphorylated (Roy & Cathcart 1998, Bhattacharjee et al. 2013). Although JAK1 binds to IL4R in response to IL13, it does not appear to be phosphorylated in response to IL13 (Roy & Cathcart 1998, Bhattacharjee et al. 2013).

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