Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate ...

created [InstanceEdit:6786049] Jassal, Bijay, 2015-07-03
dbId 6786047
displayName Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate ...
modified [InstanceEdit:6789912] Jassal, Bijay, 2015-08-06
schemaClass Summation
text Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 3 of non-reducing glucuronyl (GlcA) residues of N-glycosylated proteins terminating with the saccharide sequence glucuronyl-lactosaminyl (GlcA-LacN), forming the HNK1 carbohydrate (sulfo-3GlcA-beta1,3Gal-beta1,4-GlcNAc-R). The HNK1 carbohydrate is expressed on various adhesion molecules (neural cells, natural killer cells) in the nervous system and may play a role in cell-cell and cell-substratum interactions (Ong et al. 1998, 1999).
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