Reactome | On target cells ciliary neurotrophic factor (CNTF), and card...

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created	[InstanceEdit:6783691] Garapati, Phani Vijay, 2015-06-16
dbId	6783653
displayName	On target cells ciliary neurotrophic factor (CNTF), and card...
literatureReference	[LiteratureReference:6783554] Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects [LiteratureReference:6783607] Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component [LiteratureReference:6783539] The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines [LiteratureReference:6783587] Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
modified	[InstanceEdit:8940236] D'Eustachio, Peter, 2016-09-23
schemaClass	Summation
text	On target cells ciliary neurotrophic factor (CNTF), and cardiotrophin-like cytokine factor 1 (CLCF1) first bind their specific ligand binding component, CNTF alpha-receptor (CNTFR) subunit and induce STAT3 phosphorylation (Elson et al. 2000, Lelievre et al. 2001). CNTFR then recruits glycoprotein (gp)130, and finally complexes with leukemia inhibitory factor receptor (LIFR) beta (Stahl & Yancopoulos 1994).

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