As part of the cytosolic BRISC complex (Cooper et al. 2009),...
| created | [InstanceEdit:5691426] Jupe, Steve, 2015-05-07 |
| dbId | 5691440 |
| displayName | As part of the cytosolic BRISC complex (Cooper et al. 2009),... |
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| modified | [InstanceEdit:9794249] Shamovsky, Veronica, 2022-06-30 |
| schemaClass | Summation |
| text | As part of the cytosolic BRISC complex (Cooper et al. 2009), BRCC3 regulates NLRP3 activity by promoting K63-deubiquitination of its LRR domain (Py et al. 2013). FAM175B (ABRO1), another BRISC subunit, binds directly to NLRP3 leading to FAM175B-dependent recruitment of the BRISC complex which mediates deubiquitination of NLRP3 upon inflammasome activation (Ren G et al.2019). In addition, FAM175B (ABRO1) enhanced BRCC3 protein stability by inhibiting WWP2-mediated ubiquitination and degradation of BRCC3 through the ubiquitin-proteasome pathway (Zhang W et al. 2021).The consequent activation of NLRP3 has been proposed to mediate necrotic cell sensing and the subsequent release of the proinflammatory cytokine IL-1Beta after hypoxic injury (Iyer et al. 2009). |
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