ATG12 is transferred from ATG10, becoming conjugated to the ...

created [InstanceEdit:5683589] Jupe, Steve, 2015-03-16
dbId 5683591
displayName ATG12 is transferred from ATG10, becoming conjugated to the ...
literatureReference
modified [InstanceEdit:5683597] Jupe, Steve, 2015-03-16
schemaClass Summation
text ATG12 is transferred from ATG10, becoming conjugated to the ATG5 at Lys-130 through an isopeptide bond (Mizushima et al. 1998) that requires no E3-like enzyme. Nuclear magnetic resonance experiments, mutational analyses and crosslinking experiments show that ATG10 directly recognizes ATG5, binding it to place the side chain of ATG5 Lys-130 into an optimal orientation for its conjugation reaction with ATG12, thereby enabling ATG10 to mediate the formation of the ATG12-ATG5 conjugate without a specific E3 enzyme (Yamaguchi et al. 2012).
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