Reactome | The N-terminal domain of ATG7 recruits the E2-like protein A...

Schema > Summation > Entries

created	[InstanceEdit:5682876] Jupe, Steve, 2015-03-11
dbId	5682882
displayName	The N-terminal domain of ATG7 recruits the E2-like protein A...
literatureReference	[LiteratureReference:5682875] Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures [LiteratureReference:5682906] Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7 [LiteratureReference:5682883] Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins
modified	[InstanceEdit:5693009] Jupe, Steve, 2015-05-13
schemaClass	Summation
text	The N-terminal domain of ATG7 recruits the E2-like protein ATG10 (Kaiser et al. 2012, Yamaguchi et al. 2012). Biochemical data and modeling suggest that recruitment of ATG10 to the ATG7 N-terminal domain results in presentation of the ATG10 active site to the ATG7-ATG12 thioester linkage from the opposing monomer in the ATG7 homodimer (Klionsky & Schulman 2014).

(summation)

Cite Us!