Reactome | ATG7 acts as an E1-like enzyme for ATG12. It binds to and ac...

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created	[InstanceEdit:5681983] Jupe, Steve, 2015-03-04
dbId	5681978
displayName	ATG7 acts as an E1-like enzyme for ATG12. It binds to and ac...
literatureReference	[LiteratureReference:5682007] Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy [LiteratureReference:5682651] The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3 [LiteratureReference:5681996] The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation
modified	[InstanceEdit:9020618] Jupe, Steve, 2017-09-08
schemaClass	Summation
text	ATG7 acts as an E1-like enzyme for ATG12. It binds to and activates ATG12, allow its transfer to the E2-like ATG10. The amino-acid sequence of ATG12 ends with a glycine residue and does not require protease activation. ATG12 is activated by forming a thioester bond between its C-terminal Gly-140 and Cys-572 of ATG7 (Tanida et al. 1999, 2001). ATG7 has been shown to function in the form of a homodimer (Komatsu et al. 2001).

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