Reactome | When cellular energy is depleted mTORC1 dissociates from the...

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created	[InstanceEdit:5675857] Jupe, Steve, 2015-02-17
dbId	5675862
displayName	When cellular energy is depleted mTORC1 dissociates from the...
literatureReference	[LiteratureReference:5671591] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy [LiteratureReference:5675850] The association of AMPK with ULK1 regulates autophagy [LiteratureReference:5672133] The ULK1 complex: sensing nutrient signals for autophagy activation [LiteratureReference:5672129] Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK [LiteratureReference:5665936] The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
modified	[InstanceEdit:5683921] Jupe, Steve, 2015-03-17
schemaClass	Summation
text	When cellular energy is depleted mTORC1 dissociates from the ULK1 complex (Hosakawa et al. 2009, Lee et al. 2010, Wong et al. 2013). The phosphorylation of RPTOR (Raptor) by AMPK promotes the dissociation of mTORC1 from the ULK1 complex, which leads to a reduction in S758 phosphorylation on ULK1 (Shang et al. 2011). The S758-unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011).

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