Reactome | ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hos...

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created	[InstanceEdit:5675857] Jupe, Steve, 2015-02-17
dbId	5675835
displayName	ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hos...
literatureReference	[LiteratureReference:5671591] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy [LiteratureReference:5671669] ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery [LiteratureReference:5675832] An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation [LiteratureReference:5675856] Tor-mediated induction of autophagy via an Apg1 protein kinase complex
modified	[InstanceEdit:5692976] Jupe, Steve, 2015-05-13
schemaClass	Summation
text	ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hosakawa et al. 2009, Jung et al. 2009). Similarly Drosophila Atg1, the orthologue of ULK1, phosphorylates Drosophila Atg13 (Chang & Neufeld 2009). This phosphorylation is believed to be activating, opposing the inactivating phosphorylation of ATG13 by mTORC1 (Kamada et al. 2000, Hosakawa et al. 2009,Chang & Neufeld 2009, Jung et al. 2009) under conditions of nutrient sufficiency.

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