Reactome | AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser...

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created	[InstanceEdit:5672806] Jupe, Steve, 2015-02-06
dbId	5672827
displayName	AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser...
literatureReference	[LiteratureReference:5672801] Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs [LiteratureReference:200154] Identification of a proline-rich Akt substrate as a 14-3-3 binding partner [LiteratureReference:377225] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
schemaClass	Summation
text	AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser183 by mTORC1, leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003, Oshiro et al. 2007). As AKT1S1 suppresses mTORC1 phosphorylation of physiological substrates S6K1 and 4E-BP1 (Oshiro et al. 2007) binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).

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