Reactome | The di- and tri-methylation of lysine-21 of histone H4 (H4K2...

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created	[InstanceEdit:5651644] Jupe, Steve, 2014-11-24
dbId	5651646
displayName	The di- and tri-methylation of lysine-21 of histone H4 (H4K2...
literatureReference	[LiteratureReference:5651651] A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin [LiteratureReference:5651639] SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20 [LiteratureReference:5669191] Structural and functional profiling of the human histone methyltransferase SMYD3
modified	[InstanceEdit:5674398] Jupe, Steve, 2015-02-12
schemaClass	Summation
text	The di- and tri-methylation of lysine-21 of histone H4 (H4K20) are performed by SUV420H1 (KMT5B), SUV420H2 (KMT5C) and possibly SMYD3 (KMT3E) (Foreman et al. 2011). Trimethylation is associated with heterochromatin formation and gene repression (Schotta et al. 2004). Monomethylation is performed by SETD8 (KMT5A) (Yin et al. 2005).

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