Reactome | The sorting MyD88 adaprtor-like (MAL or TIRAP) normally recr...

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created	[InstanceEdit:5607968] Shamovsky, Veronica, 2014-07-14
dbId	5607954
displayName	The sorting MyD88 adaprtor-like (MAL or TIRAP) normally recr...
literatureReference	[LiteratureReference:5602589] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes [LiteratureReference:2428866] MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:5602580] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
modified	[InstanceEdit:5625556] Shamovsky, Veronica, 2014-10-06
schemaClass	Summation
text	The sorting MyD88 adaprtor-like (MAL or TIRAP) normally recruits MyD88 to activated TLR2 and TLR4 receptor complexes (Horng T et al. 2002; Verstak B et al. 2009). MyD88 interacts with MAL (TIRAP) via their TIR domains and activates a downstream signaling pathway mediated by TLR2 and TLR4 (Ohnishi H et al. 2009). A GST pull-down assay showed that defective MyD88 R196C variant loses its ability to bind to MAL (Yamamoto T et al. 2014).

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