Reactome | Upon stimulation by pathogen-associated inflammatory signals...

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created	[InstanceEdit:5362483] Shamovsky, V, 2014-04-16
dbId	5362511
displayName	Upon stimulation by pathogen-associated inflammatory signals...
literatureReference	[LiteratureReference:5362506] Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
modified	[InstanceEdit:9013878] Shamovsky, Veronica, 2017-07-26
schemaClass	Summation
text	Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which results in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.

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