In fish, amphibian and avian species, ATP1B4 (aka X,K-ATPase...

created [InstanceEdit:5252021] Jassal, Bijay, 2014-02-05
dbId 5251987
displayName In fish, amphibian and avian species, ATP1B4 (aka X,K-ATPase...
modified [InstanceEdit:5669285] D'Eustachio, Peter, 2015-01-30
schemaClass Summation
text In fish, amphibian and avian species, ATP1B4 (aka X,K-ATPase subunit beta-m) functions as a subunit of Na/K-ATPase, located in the plasma membrane. In mammals, this functionality is lost and ATP1B4 accumulates on the nuclear envelope where it can interact with SNW domain-containing protein 1 (SNW1 aka Ski-interacting protein, SKIP), a transcriptional regulator. This ATP1B4:SNW1 complex is able to modulate TGF-beta-mediated transcription by increasing mRNA levels of SMAD7, an inhibitor of TGF-beta signalling (Pestov et al. 2007).
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