ATP-binding cassette sub-family F member 1 (ABCF1 aka ABC50)...

created [InstanceEdit:5227003] Jassal, Bijay, 2014-01-09
dbId 5226903
displayName ATP-binding cassette sub-family F member 1 (ABCF1 aka ABC50)...
schemaClass Summation
text ATP-binding cassette sub-family F member 1 (ABCF1 aka ABC50) is unlike most ABC proteins in that it does not possess membrane-spanning domains. ABCF1 interacts with eukaryotic initiation factor 2 complex (EIF2S1:EIF2S2:EIF2S3), a key player in translation initiation and control and in ribosome regulation. ABCF1 is predominantly located in the cytosol, whereas a smaller amount is also found in the nucleoplasm but not in the nucleolus. Knockout of ABCF1 impaired translation of both cap-dependent and cap-independent reporters, consistent with a positive role for ABCF1 in the function of the EIF2 complex (Paytubi et al. 2008, Paytubi et al. 2009).
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