Reactome | PI3-kinase (PI3K) catalyzes the phosphorylation of inositol ...

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created	[InstanceEdit:5218480] Garapati, P V, 2013-12-19
dbId	5218570
displayName	PI3-kinase (PI3K) catalyzes the phosphorylation of inositol ...
literatureReference	[LiteratureReference:389304] Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav [LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2
modified	[InstanceEdit:5228340] Jupe, S, 2014-01-10
schemaClass	Summation
text	PI3-kinase (PI3K) catalyzes the phosphorylation of inositol phospholipids at the 3 position to generate phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate. PIP2 and PIP3 generated serve as lipid substrates where they recruit guanine nucleotide exchange factors (GEFs) like VAV (Proto-oncogene vav) that catalyze the exchange of GDP for GTP on Rac, activating it (Han et al. 1998). VAV2 acts downstream of VEGF to activate Rac1 (Garretta et al. 2007).

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