Reactome | Leppla, SH

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Leppla, SH Show undefined attributes

affiliation	[Affiliation:5490364] National Institutes of Health,National Institute of Allergy and Infectious Diseases
created	[InstanceEdit:5205725] D'Eustachio, Peter, 2013-12-05
dbId	5205698
displayName	Leppla, SH
firstname	Stephen H
initial	SH
modified	[InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19
publications	[LiteratureReference:5490361] Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells [LiteratureReference:5211226] Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells [LiteratureReference:5209988] Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization [LiteratureReference:5358383] Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins [LiteratureReference:874007] Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome [LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor [LiteratureReference:5209992] Crystal structure of a complex between anthrax toxin and its host cell receptor [LiteratureReference:5205695] Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase [LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity [LiteratureReference:5205696] Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen [LiteratureReference:5567356] Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway [LiteratureReference:5487064] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [LiteratureReference:5210014] The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin [LiteratureReference:5205714] Crystal structure of the anthrax toxin protective antigen [LiteratureReference:5205729] Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin [LiteratureReference:5308144] Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 [LiteratureReference:5487075] Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo
schemaClass	Person
surname	Leppla

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