Reactome | The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor p...

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created	[InstanceEdit:508450] Jupe, S, 2010-02-12
dbId	508441
displayName	The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor p...
literatureReference	[LiteratureReference:508442] Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway [LiteratureReference:508437] Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function [LiteratureReference:508445] A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation
modified	[InstanceEdit:1213522] Jupe, S, 2011-02-11
schemaClass	Summation
text	The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses.

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