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Sabatini, DM
Show undefined attributes
affiliation
[Affiliation:9658543] Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
created
[InstanceEdit:5083642] Shamovsky, V, 2013-11-07
crossReference
[DatabaseIdentifier:9658738] ORCID:0000-0002-1446-7256
dbId
5083667
displayName
Sabatini, DM
firstname
David M
initial
DM
modified
[InstanceEdit:9658740] May, Bruce, 2019-08-17
orcidId
0000-0002-1446-7256
publications
[LiteratureReference:9647598] Twenty-five years of mTOR: Uncovering the link from nutrients to growth
[LiteratureReference:9647592] The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
[LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
[LiteratureReference:5655434] mTOR signaling in growth control and disease
[LiteratureReference:5672046] Regulation of mTORC1 and its impact on gene expression at a glance
[LiteratureReference:5672795] mTOR signaling at a glance
[LiteratureReference:9646247] Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
[LiteratureReference:5655438] Growing roles for the mTOR pathway
[LiteratureReference:5655429] mTOR: from growth signal integration to cancer, diabetes and ageing
[LiteratureReference:9640185] Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
[LiteratureReference:5083669] Structure of the human mTOR complex I and its implications for rapamycin inhibition
[LiteratureReference:5655439] Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
[LiteratureReference:9646210] Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
[LiteratureReference:9646570] mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
[LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
[LiteratureReference:9639282] Sestrin2 is a leucine sensor for the mTORC1 pathway
[LiteratureReference:5653951] The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
[LiteratureReference:9640261] The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
[LiteratureReference:9646226] mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
[LiteratureReference:9639285] Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
[LiteratureReference:9646214] The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
[LiteratureReference:9646572] A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
[LiteratureReference:9640286] SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
[LiteratureReference:9646218] The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
[LiteratureReference:9938156] MCART1/SLC25A51 is required for mitochondrial NAD transport
[LiteratureReference:5624228] MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
[LiteratureReference:9646267] KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
[LiteratureReference:8952709] Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
schemaClass
Person
surname
Sabatini
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