Reactome | Sabatini, DM

Schema > Person > Entries

Sabatini, DM Show undefined attributes

affiliation	[Affiliation:9658543] Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
created	[InstanceEdit:5083642] Shamovsky, V, 2013-11-07
crossReference	[DatabaseIdentifier:9658738] ORCID:0000-0002-1446-7256
dbId	5083667
displayName	Sabatini, DM
firstname	David M
initial	DM
modified	[InstanceEdit:9658740] May, Bruce, 2019-08-17
orcidId	0000-0002-1446-7256
publications	[LiteratureReference:9647598] Twenty-five years of mTOR: Uncovering the link from nutrients to growth [LiteratureReference:9647592] The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway [LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms [LiteratureReference:5655434] mTOR signaling in growth control and disease [LiteratureReference:5672046] Regulation of mTORC1 and its impact on gene expression at a glance [LiteratureReference:5672795] mTOR signaling at a glance [LiteratureReference:9646247] Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability [LiteratureReference:5655438] Growing roles for the mTOR pathway [LiteratureReference:5655429] mTOR: from growth signal integration to cancer, diabetes and ageing [LiteratureReference:9640185] Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases [LiteratureReference:5083669] Structure of the human mTOR complex I and its implications for rapamycin inhibition [LiteratureReference:5655439] Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 [LiteratureReference:9646210] Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 [LiteratureReference:9646570] mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase [LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids [LiteratureReference:9639282] Sestrin2 is a leucine sensor for the mTORC1 pathway [LiteratureReference:5653951] The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 [LiteratureReference:9640261] The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 [LiteratureReference:9646226] mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient [LiteratureReference:9639285] Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway [LiteratureReference:9646214] The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 [LiteratureReference:9646572] A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 [LiteratureReference:9640286] SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway [LiteratureReference:9646218] The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway [LiteratureReference:9938156] MCART1/SLC25A51 is required for mitochondrial NAD transport [LiteratureReference:5624228] MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors [LiteratureReference:9646267] KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 [LiteratureReference:8952709] Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
schemaClass	Person
surname	Sabatini

Cite Us!