The E3 ubiquitin ligases SMURF1/2 are recruited to the DVL:P...

created [InstanceEdit:4608853] Rothfels, K, 2013-09-23
dbId 4608851
displayName The E3 ubiquitin ligases SMURF1/2 are recruited to the DVL:P...
modified [InstanceEdit:5099851] Rothfels, K, 2013-11-13
schemaClass Summation
text The E3 ubiquitin ligases SMURF1/2 are recruited to the DVL:PARD6A complex after WNT5A stimulation. Recruitment depends on DVL2 phosphorylation and is mediated by the DEP domain of DVL2 that is important for PCP signaling (Narimatsu et al, 2009; Boutros et al, 1998). Smurf1 and 2 mutant mice show defects in convergent extension and neural tube closure, as well as misorientation of sensory hairs in the inner ear, phenotypes consistent with a role for SMURFs in the PCP pathway (Narimatsu et al, 2009).
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