Reactome | The NuA4 complex contains the histone acetyltransferase (HAT...

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created	[InstanceEdit:4551304] Jupe, S, 2013-09-13
dbId	4551312
displayName	The NuA4 complex contains the histone acetyltransferase (HAT...
literatureReference	[LiteratureReference:3321994] Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis [LiteratureReference:3321973] Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex [LiteratureReference:3321996] Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans [LiteratureReference:3322941] The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes
modified	[InstanceEdit:4551362] Jupe, S, 2013-09-13
schemaClass	Summation
text	The NuA4 complex contains the histone acetyltransferase (HAT) KAT5 (TIP60), a member of the MYST family. The first characterisation of a mammalian NuA4 complex identified the additonal components TRRAP, the Enhancer of Polycomb protein (EPC1), actin-like protein ACTL6A (BAF53a), which is a homolog of yeast Arp4, actin (ACTB), the SNF2-related helicase p400 (EP400) and the AAA ATPases RUVBL1 (TIP49a) and RUVBL2 (TIP49b) (Ikura et al. 2000). Subsequently further copmponents were identified as MRGBP, MORF4L1 (MRG15), MORF4L2 (MRGX), (Cai et al. 2003), BRD8, DMAP1, ING3, MEAF6, YEATS4 (Doyon et al. 2004) and VPS72 (YL1) (Cai et al. 2005).

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