Reactome | Kerr, IM

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Kerr, IM Show undefined attributes

created	[InstanceEdit:449839] Jupe, S, 2009-12-07
dbId	449823
displayName	Kerr, IM
initial	IM
modified	[InstanceEdit:449857] Jupe, S, 2009-12-07
publications	[LiteratureReference:914198] Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins [LiteratureReference:904798] Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling [LiteratureReference:873892] A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma [LiteratureReference:1015638] Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease [LiteratureReference:1031687] Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells [LiteratureReference:909657] Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein [LiteratureReference:1067689] Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction [LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:449783] Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions [LiteratureReference:1112730] Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression [LiteratureReference:1067673] A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130 [LiteratureReference:873912] Signaling through a mutant IFN-gamma receptor [LiteratureReference:873845] Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state
schemaClass	Person
surname	Kerr

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