Reactome | The Interleukin-15 (IL15) / Interleukin-15 receptor subunit ...

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created	[InstanceEdit:449109] Jupe, S, 2009-11-27
dbId	449141
displayName	The Interleukin-15 (IL15) / Interleukin-15 receptor subunit ...
literatureReference	[LiteratureReference:9006754] Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15 [LiteratureReference:449144] Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor [LiteratureReference:449142] Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes [LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified	[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
schemaClass	Summation
text	The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15R?) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2R?), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2R?), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.

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