Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ...

created [InstanceEdit:4396385] Orlic-Milacic, M, 2013-08-22
dbId 4396381
displayName Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ...
modified [InstanceEdit:9982319] May, Bruce, 2026-02-16
schemaClass Summation
text Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ (CSL) binding sites (Maier and Gessler 2000). Cotransfection experiments in mouse fibroblast cell line NIH3T3, human embryonic kidney cell line HEK293 and African green monkey kidney cell line COS-7 showed that a recombinant mouse NICD1 activates transcription of a reporter luciferase gene fused to promoters of either mouse Hey1, Hey2 or Heyl. NICD1-mediated transcriptional activation is lost when RBPJ sites in Hey1 promoter are deleted by PCR-directed mutagenesis (Maier and Gessler 2000).
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