Reactome | Adrenaline (epinephrine) signalling via the alpha-2 adrenerg...

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created	[InstanceEdit:428056] Jupe, S, 2009-06-30
dbId	428060
displayName	Adrenaline (epinephrine) signalling via the alpha-2 adrenerg...
literatureReference	[LiteratureReference:428057] alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels [LiteratureReference:428058] Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells [LiteratureReference:390787] Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
modified	[InstanceEdit:9916931] D'Eustachio, Peter, 2024-07-27
schemaClass	Summation
text	Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, induction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.

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