Reactome | Diacylglycerol (DAG) is an important source of arachidonic a...

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created	[InstanceEdit:426042] Jupe, S, 2009-06-11
dbId	426039
displayName	Diacylglycerol (DAG) is an important source of arachidonic a...
literatureReference	[Book:426044] 9783527605767 Krauss, Gerhard Biochemistry of signal transduction and regulation [LiteratureReference:434776] Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes [LiteratureReference:434788] Differential hydrolysis of phospholipid molecular species during activation of human platelets with thrombin and collagen
modified	[InstanceEdit:434772] Jupe, S, 2009-09-02
schemaClass	Summation
text	Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.

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