Reactome | The classical signalling mechanism for G alpha (i) is inhibi...

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created	[InstanceEdit:425211] Jupe, S, 2009-06-03
dbId	425210
displayName	The classical signalling mechanism for G alpha (i) is inhibi...
literatureReference	[LiteratureReference:8964277] Src tyrosine kinase is a novel direct effector of G proteins [LiteratureReference:8982636] Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase [LiteratureReference:8949498] Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits
modified	[InstanceEdit:9032085] Jupe, Steve, 2017-12-05
schemaClass	Summation
text	The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase (Dessauer C W et al. 2002). Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. Other functions of G alpha (i) includes activation of the protein tyrosine kinase c-Src (Ma Y C et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (i) (Soundararajan et al. 2008).

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