DNA 5-methylcytosine dioxygenase activity

accession 0070579
created [InstanceEdit:422569] Kanapin, EE
databaseName GO
dbId 423145
definition Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC).
displayName DNA 5-methylcytosine dioxygenase activity
ecNumber 1.14.11.80
modified [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name DNA 5-methylcytosine dioxygenase activity
referenceDatabase [ReferenceDatabase:1] GO
schemaClass GO_MolecularFunction
url https://www.ebi.ac.uk/QuickGO/term/GO:0070579
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