Reactome | Unc-115/AbLIM is a key regulator of lamellipodia and filopod...

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created	[InstanceEdit:418739] Garapati, P V, 2009-04-27 08:54:58
dbId	418736
displayName	Unc-115/AbLIM is a key regulator of lamellipodia and filopod...
literatureReference	[LiteratureReference:418746] The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM [LiteratureReference:418747] The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans [LiteratureReference:373498] The Netrin family of guidance factors: emphasis on Netrin-1 signalling
modified	[InstanceEdit:421643] Garapati, P V, 2009-05-19 13:35:48
schemaClass	Summation
text	Unc-115/AbLIM is a key regulator of lamellipodia and filopodia in the growth cone during axon pathfinding and acts downstream of Rac GTPase signaling. It acts as a scaffold to recruit other actin-modulating complexes involved in lamellipodia and filopodia. Unc-115/AbLIM is locally recruited to the plasma membrane by activated Rac1 and subsequently dephosphorylated on serine 617. Dephosphorylated Unc-115/AbLIM then might interact with other molecules at the plasma membrane to induce formation of lamellipodia and filopodia by reorganization of the actin cytoskeleton.

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